摘要
近年来,雷帕霉素作为免疫抑制剂应用于临床.雷帕霉素在试验中具有加速脂代谢的效果,但同时又具有高血脂的不良反应.针对这一双面性的结论,本文主要从以下几方面进行简单分析:直接抑制mTOR通路、减少过氧化物酶体增殖物激活受体γ表达、抑制瘦素分泌、下调胆固醇调节元件结合蛋白以及激发细胞自噬.基于目前国内外研究,建议可以从雷帕霉素的剂量-反应效应影响及PI3 K/PKB/mTOR信号通路参与的各细胞因子间相互作用的确切机制等其他方面进行后续研究,进一步了解量化雷帕霉素与血脂代谢的关系.
In recent years,rapamycin has been used as an immunosuppressive agent in clinical practice.Rapamycin has the effect of accelerating lipid metabolism in the test,but it has the adverse reaction of hyperlipidemia at the same time.In view of this double-side conclusion,this article mainly analyzes the following aspects:direct inhibition of mTOR pathway,reduce expression of peroxisome proliferator-activated receptor γ,inhibition of leptin secretion,down-regulation of cholesterol-regulating element binding protein and excitation cell autophagy.Based on current research at home and abroad,it suggested that the the effects of dose-response effects of rapamycin and the exact mechanism of interaction between PI3K/PKB/mTOR signaling pathways and other cytokines can be a further research direction,so that the relationship between rapamycin and blood lipid metabolism can be learn more about in a quantify way.
出处
《国际外科学杂志》
2017年第9期633-636,共4页
International Journal of Surgery
基金
国家自然科学基金青年基金，National Natural Science Foundation for Youths
关键词
肾移植
脂代谢障碍
细胞因子类
自噬
雷帕霉素
Kidney transplantation
Lipid metabolism disorders
Cytokines
Autophagy
Rapamycin
