摘要
目的 探讨经尿道膀胱肿瘤电切术后,对于有保留膀胱意向的高级别膀胱尿路上皮癌患者,髂内动脉灌注化疗联合膀胱灌注的临床疗效.方法 回顾性分析2010年2月-2016年12月收治的膀胱高级别尿路上皮癌,给予化疗及对症支持治疗的病例共74例.根据化疗方法不同分为动脉灌注组(n=43):接受经尿道膀胱肿瘤电切术+双侧髂内动脉介入灌注化疗+膀胱灌注联合疗法;静脉化疗组(n=31):接受经尿道膀胱肿瘤电切术+静脉吉西他滨-顺铂化疗+膀胱灌注联合疗法.比较两组患者术后肿瘤复发率、术后无瘤时间、术后并发症的发生情况.计量资料采用((x)±s)表示,组间比较采用t检验;计数资料以率的方式表示,比较采用x2检验.采用Kaplan-Meier法描绘两组患者术后无瘤生存时间.结果 两组患者术后无瘤生存时间差异无统计学意义.在骨髓抑制(x2=4.956,P=0.029),胃肠道反应(x2=5.912,P=0.012),皮炎、黏膜炎(x2=4.276,P=0.013)方面,髂内动脉介入灌注化疗有优势.结论 经髂内动脉灌注化疗患者有效率与静脉化疗患者相近,对保留膀胱有一定价值,且术后不良反应发生率低,具有一定优势.
Objective To evaluate the clinical effect of iliac artery interventional chemotherapy combination with bladder perfusion for high level of bladder urothelial carcinoma after transurethral bladder tumor electricity cut operation for those who intend to retain the bladder.Methods From February 2010 to December 2016,a total of 74 cases high-grade urothelial carcinoma of the bladder,giving chemotherapy and suitted support were retrospectively analyzed.The patients were divided into two groups according to different chemotherapy methods.Artery perfusion chemotherapy group:43 cases treated by transurethral bladder tumor cutting + bilateral iliac artery interventional perfusion chemotherapy + bladder perfusion in combination therapy;Intravenous chemotherapy group:31 cases underwent transurethral bladder tumor cut method + cisplatin,vein gemcitabine + bladder perfusion chemotherapy combined therapy.According to the ((x) ± s) between the groups.The method of count data is represented by chi-square test.Kaplan-meier method was used to describe the survival time of two groups of patients after operation.Results Two groups of patients with postoperative there was no statistically significant difference in disease-free survival time.In the bone marrow suppression (x2 =4.956,P =0.029);gastrointestinal tract reaction (x2 =5.912,P =0.012);dermatitis,mucositis (x2 =4.276,P =0.013),etc.,has the advantages in the iliac artery interventional perfusion chemotherapy (P ＜ 0.05).Conclusion Via efficient iliac arterial infusion chemotherapy in patients with venous chemotherapy patients,to the retention of the bladder has a certain value,and the incidence of adverse reactions after surgery is low,have certain advantages.
出处
《国际外科学杂志》
2017年第9期583-586,后插1,共5页
International Journal of Surgery
关键词
膀胱肿瘤
化学疗法
癌
局部灌注
病例对照研究
经髂内动脉灌注
高级别
Urinary bladder neoplasms
Chemotherapy,cancer,regional perfusion
Case-control studies
Internal iliac artery chemotherapy
High level
