摘要
<strong>Objectives: </strong>To investigate influence of metabolic syndrome on vibration perception threshold in first-degree relatives of type 2 diabetes who were not diagnosed with diabets before. <strong>Material and Methods:</strong> First-degree relatives of type 2 diabetes at the age of 40 - 60 s who had not been diagnosed with diabetes before were enrolled. Height, weight, waist circumference, hip circumference, blood pressure (systolic and diastolic blood pressure), body fat percentage, fasting plasma lipid, fasting plasma glucose, 2-hour blood glucose after 75 g oral glucose and vibration perception threshold were measured. <strong>Results:</strong> 58 subjects were diagnosed with the level of vibration perception threshold ≥ 16 V. Vibration perception threshold in the metabolic syndrome group was significantly higher than that in the non-metabolic syndrome group (<em>P</em> < 0.05). Vibration perception threshold increased with the increase of metabolic syndrome component. The group with ≥3 components of metabolic syndrome had a significantly higher level of vibration perception, as compared with that of group with 0 component, group with 1 component of metabolic syndrome (<em>p</em> < 0.01). Group with 2 components of metabolic syndrome had a significantly higher level of vibration perception threshold when comparing with group with 0 component (<em>P</em> < 0.05). Vibration perception threshold was positively correlated with weight, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose and 2-hour blood glucose. Stepwise multiple regression analysis showed that there was a positive correlation between waist circumference, systolic blood pressure and vibration perception threshold. <strong>Conclusion:</strong> Some first-degree relatives of type 2 diabetes who have not been diagnosed with diabetes have high risk of peripheral neuropathy, especially those with metabolic syndrome. Waist circumference and blood pressure are the main factors affe
<strong>Objectives: </strong>To investigate influence of metabolic syndrome on vibration perception threshold in first-degree relatives of type 2 diabetes who were not diagnosed with diabets before. <strong>Material and Methods:</strong> First-degree relatives of type 2 diabetes at the age of 40 - 60 s who had not been diagnosed with diabetes before were enrolled. Height, weight, waist circumference, hip circumference, blood pressure (systolic and diastolic blood pressure), body fat percentage, fasting plasma lipid, fasting plasma glucose, 2-hour blood glucose after 75 g oral glucose and vibration perception threshold were measured. <strong>Results:</strong> 58 subjects were diagnosed with the level of vibration perception threshold ≥ 16 V. Vibration perception threshold in the metabolic syndrome group was significantly higher than that in the non-metabolic syndrome group (<em>P</em> < 0.05). Vibration perception threshold increased with the increase of metabolic syndrome component. The group with ≥3 components of metabolic syndrome had a significantly higher level of vibration perception, as compared with that of group with 0 component, group with 1 component of metabolic syndrome (<em>p</em> < 0.01). Group with 2 components of metabolic syndrome had a significantly higher level of vibration perception threshold when comparing with group with 0 component (<em>P</em> < 0.05). Vibration perception threshold was positively correlated with weight, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose and 2-hour blood glucose. Stepwise multiple regression analysis showed that there was a positive correlation between waist circumference, systolic blood pressure and vibration perception threshold. <strong>Conclusion:</strong> Some first-degree relatives of type 2 diabetes who have not been diagnosed with diabetes have high risk of peripheral neuropathy, especially those with metabolic syndrome. Waist circumference and blood pressure are the main factors affe
作者
Lili Yang
Peng Yun
Dan Liu
Zhen Zhang
Xuemei Yu
Fangping Li
Lili Yang;Peng Yun;Dan Liu;Zhen Zhang;Xuemei Yu;Fangping Li(Department of Endocrinology, The Seventh Hospital Affiliated to Sun Yat-sen University, Shen zhen, China;Department of Endocrinology, South Campus, Sixth People’s Hospital, Shanghai Jiao tong University, Shanghai, China)
