摘要
Recent publications reveal the disturbing information that a minor edit to an algorithm being used for designing legitimate drug candidates redirected the program in a way that resulted in the surprising design of novel chemical warfare agent candidates. Although this outcome was not the result of nefarious intent, and appropriate chemical defense authorities were notified, the potential implications of some misapplication of a drug-design algorithm for nefarious purposes are clear. This Commentary summarizes how otherwise benign Artificial Intelligence (AI) algorithms used for drug discovery can be easily reversed to design novel chemical warfare agents for which no effective antidote will be available, or perhaps even envisioned.
Recent publications reveal the disturbing information that a minor edit to an algorithm being used for designing legitimate drug candidates redirected the program in a way that resulted in the surprising design of novel chemical warfare agent candidates. Although this outcome was not the result of nefarious intent, and appropriate chemical defense authorities were notified, the potential implications of some misapplication of a drug-design algorithm for nefarious purposes are clear. This Commentary summarizes how otherwise benign Artificial Intelligence (AI) algorithms used for drug discovery can be easily reversed to design novel chemical warfare agents for which no effective antidote will be available, or perhaps even envisioned.
作者
Robert B. Raffa
Joseph V. Pergolizzi Jr.
Thomas Miller
Daniel Motto
Robert B. Raffa;Joseph V. Pergolizzi Jr.;Thomas Miller;Daniel Motto(School of Pharmacy (Emeritus Prof.), Temple University, Philadelphia, PA, USA;College of Pharmacy (Adjunct), University of Arizona, Tucson, AZ, USA;Neumentum, Summit, NJ, USA;Enalare Therapeutics, Princeton, NJ, USA;NEMA Research, Naples, FL, USA;Sydney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA)
