摘要
Background: Malaria is the most widespread parasitic disease and remains a public health priority worldwide. The severe form is fatal if not treated early and appropriately. The aim was to carry out a descriptive and analytical study of the factors associated with mortality during severe malaria in children attending emergency departments in Dakar, Senegal. Methods: This is a prospective, observational and analytical study conducted over a 6-month period (July 1 to December 31, 2022), focusing on children hospitalized for severe malaria according to WHO severity criteria. Results: A total of 403 patients were hospitalized, including 78 cases of severe malaria (19.35%). Males predominated (60.26%) (sex ratio 1.51). The average age was 6.56 years [8 months - 14 years], with the [5 - 10 years] age group the most represented (40.26%). The average consultation time was 5.33 days (1 - 19 days). The main reasons for consultation were fever (70.51%), vomiting (24.35%) and convulsions (14.10%). Biological signs of severity were severe anemia (17.95%), renal failure (6.4%) and hypoglycemia (3.85%). Thrombocytopenia was noted in 52.56% of patients, including 32.05% of severe cases (sis in 61.41% of cases. Hyponatremia was noted in 39.74% of cases and hyperkalemia in 2 patients. Artesunate was the main drug used (93.59% of cases). Mortality was estimated at 1.5%. Factors leading to death were coma (P < 0.01), respiratory distress (P Conclusion: Malaria is still a public health problem, with a high mortality rate in emergency departments. Reducing this mortality rate requires effective management of the factors associated with death.
Background: Malaria is the most widespread parasitic disease and remains a public health priority worldwide. The severe form is fatal if not treated early and appropriately. The aim was to carry out a descriptive and analytical study of the factors associated with mortality during severe malaria in children attending emergency departments in Dakar, Senegal. Methods: This is a prospective, observational and analytical study conducted over a 6-month period (July 1 to December 31, 2022), focusing on children hospitalized for severe malaria according to WHO severity criteria. Results: A total of 403 patients were hospitalized, including 78 cases of severe malaria (19.35%). Males predominated (60.26%) (sex ratio 1.51). The average age was 6.56 years [8 months - 14 years], with the [5 - 10 years] age group the most represented (40.26%). The average consultation time was 5.33 days (1 - 19 days). The main reasons for consultation were fever (70.51%), vomiting (24.35%) and convulsions (14.10%). Biological signs of severity were severe anemia (17.95%), renal failure (6.4%) and hypoglycemia (3.85%). Thrombocytopenia was noted in 52.56% of patients, including 32.05% of severe cases (sis in 61.41% of cases. Hyponatremia was noted in 39.74% of cases and hyperkalemia in 2 patients. Artesunate was the main drug used (93.59% of cases). Mortality was estimated at 1.5%. Factors leading to death were coma (P < 0.01), respiratory distress (P Conclusion: Malaria is still a public health problem, with a high mortality rate in emergency departments. Reducing this mortality rate requires effective management of the factors associated with death.
作者
Aliou Thiongane
Abou Ba
Fatou Ly
Aliou A. Ndongo
Djibril Boiro
Younoussa Kéita
Idrissa Basse
Babacar Niang
Indou Dême Ly
Yaye Joor Dieng
Djenaba Fafa Cissé
Ndiogou Seck
Lamine Thiam
Papa Moctar Faye
Amadou Lamine Fall
Assane Sylla
Ousmane Ndiaye
Aliou Thiongane;Abou Ba;Fatou Ly;Aliou A. Ndongo;Djibril Boiro;Younoussa Kéita;Idrissa Basse;Babacar Niang;Indou Dême Ly;Yaye Joor Dieng;Djenaba Fafa Cissé;Ndiogou Seck;Lamine Thiam;Papa Moctar Faye;Amadou Lamine Fall;Assane Sylla;Ousmane Ndiaye(Centre Hospitalier National d’Enfants Albert Royer, Dakar, Sénégal;Service de pédiatrie Hô,pital Dalal Jamm, Dakar, Sénégal;Service de pédiatrie Hô,pital Pikine, Dakar, Sénégal;Service de pédiatrie Hô,pital Abass Ndao, Dakar, Sénégal;Centre Hospitalier National d’Enfants de Diamniadio, Dakar, Sénégal;Service de pédiatrie Hô,pital régional, Saint Louis, Sénégal;Service de pédiatrie Hô,pital de la paix de Ziguinchor, Ziguinchor, Sénégal)
