摘要
Imminent abortion needs more serious attention since it remains a big problem in Indonesia considering its epidemiology, morbidity, mortality,?and prognosis. In fact, some cases can still be prevented.?The objective of this study was to determine pathogenesis, diagnosis,?and prognosis of imminent abortion through the role of antioxidant vitamin C in the interaction of superoxide dismutase (SOD), interferon-γ?(IFN-γ), interleukin-4 (IL-4), vascular cells adhesion molecule-1?(VCAM-1), and decidual spiral artery resistance index (DSA RI).?This study took 10 months from March to December 2007 at Obstetrics and Gynecology Department of Medical Faculty of?Padjadjaran?University/Hasan Sadikin Hospital, Bandung. Sixty pregnant women who met the inclusion and exclusion criteria were divided into two groups with the random clinical trial method, double-blind with?repeated measurements.?Data were analyzed statistically using t test, Mann-Whitney, Rank?Spearman, Wilcoxon, t paired, and diagnostic test.?The results of this study showed that the incidence of abortion in vitamin C group was 9 cases (30%) and placebo group was 13 cases (43.3%). There was a significant difference in SOD, IFN-γ, IL-4 and VCAM-1 level between groups of women with and without abortion (p < 0.001).?There was a significant difference of SOD level between women with abortion 655.8 (163.6) U/gHb and placebo group 824.5 (106.7) U/gHb after vitamin C administration (p = 0.008). The cutoff point of SOD?was?￡992 U/gHbwhich?showed quite high sensitivity, specificity, accuracy,?and significant difference (p < 0.001). The cutoff point abortion of DSA resistance index was ≥0.55 with 45% accuracy (p = 0.002). The highest change of IL-4 level was 60.7% in vitamin C group and VCAM-1 was?-2.2% (p < 0.05) after?vitamin C administration. There was a negative correlation in SOD changes toward IL-4 changes after vitamin C administration (r =?-0.523) (p = 0.003), a positive correlation between SOD changes and IL-4 changes (0.597) (p < 0.001), a negative correlati
Imminent abortion needs more serious attention since it remains a big problem in Indonesia considering its epidemiology, morbidity, mortality,?and prognosis. In fact, some cases can still be prevented.?The objective of this study was to determine pathogenesis, diagnosis,?and prognosis of imminent abortion through the role of antioxidant vitamin C in the interaction of superoxide dismutase (SOD), interferon-γ?(IFN-γ), interleukin-4 (IL-4), vascular cells adhesion molecule-1?(VCAM-1), and decidual spiral artery resistance index (DSA RI).?This study took 10 months from March to December 2007 at Obstetrics and Gynecology Department of Medical Faculty of?Padjadjaran?University/Hasan Sadikin Hospital, Bandung. Sixty pregnant women who met the inclusion and exclusion criteria were divided into two groups with the random clinical trial method, double-blind with?repeated measurements.?Data were analyzed statistically using t test, Mann-Whitney, Rank?Spearman, Wilcoxon, t paired, and diagnostic test.?The results of this study showed that the incidence of abortion in vitamin C group was 9 cases (30%) and placebo group was 13 cases (43.3%). There was a significant difference in SOD, IFN-γ, IL-4 and VCAM-1 level between groups of women with and without abortion (p < 0.001).?There was a significant difference of SOD level between women with abortion 655.8 (163.6) U/gHb and placebo group 824.5 (106.7) U/gHb after vitamin C administration (p = 0.008). The cutoff point of SOD?was?￡992 U/gHbwhich?showed quite high sensitivity, specificity, accuracy,?and significant difference (p < 0.001). The cutoff point abortion of DSA resistance index was ≥0.55 with 45% accuracy (p = 0.002). The highest change of IL-4 level was 60.7% in vitamin C group and VCAM-1 was?-2.2% (p < 0.05) after?vitamin C administration. There was a negative correlation in SOD changes toward IL-4 changes after vitamin C administration (r =?-0.523) (p = 0.003), a positive correlation between SOD changes and IL-4 changes (0.597) (p < 0.001), a negative correlati
