摘要
<b><span style="font-family:Verdana;">Objective</span></b><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:""> </span></b><span style="font-family:""><span style="font-family:Verdana;">To compare the distribution of “mean corpuscular hemoglobin”-MCV, “mean corpuscular volume”-MCH, “hemoglobin”-HGB, “hemoglobin A”-HbA and “hemoglobin A2”-HbA2 in </span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;"> thalassemia hematology screening between Li and Han nationality, and analyze the best diagnostic cut-off value. </span><b><span style="font-family:Verdana;">Methods</span></b></span><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:""> </span></b><span style="font-family:""><span style="font-family:Verdana;">Select 7816 middle school students from Li nationality area as the research object, collect peripheral blood for blood cell analysis, hemoglobin electrophoresis and thalassaemia gene detection, and compare the difference in hematological parameters of common thalassemia genotype between Li and Han nationalities. Taking the genetic test results as the gold standard, construct the receiver operator characteristic curve (ROC curve) of relevant hematology parameters, calculate the Youden index and take its maximum diagnostic cut-off point as the best critical value.</span><b><span style="font-family:Verdana;"> Results</span></b></span><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:""> </span></b><span style="font-family:""><span style="font-family:Verdana;">Comparison of hematological parameters of common thalassemia genotypes showed that the average value of MCH and MCV of -</span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;">3.7/-</span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;">4.2 type in Li n
<b><span style="font-family:Verdana;">Objective</span></b><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:""> </span></b><span style="font-family:""><span style="font-family:Verdana;">To compare the distribution of “mean corpuscular hemoglobin”-MCV, “mean corpuscular volume”-MCH, “hemoglobin”-HGB, “hemoglobin A”-HbA and “hemoglobin A2”-HbA2 in </span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;"> thalassemia hematology screening between Li and Han nationality, and analyze the best diagnostic cut-off value. </span><b><span style="font-family:Verdana;">Methods</span></b></span><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:""> </span></b><span style="font-family:""><span style="font-family:Verdana;">Select 7816 middle school students from Li nationality area as the research object, collect peripheral blood for blood cell analysis, hemoglobin electrophoresis and thalassaemia gene detection, and compare the difference in hematological parameters of common thalassemia genotype between Li and Han nationalities. Taking the genetic test results as the gold standard, construct the receiver operator characteristic curve (ROC curve) of relevant hematology parameters, calculate the Youden index and take its maximum diagnostic cut-off point as the best critical value.</span><b><span style="font-family:Verdana;"> Results</span></b></span><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:""> </span></b><span style="font-family:""><span style="font-family:Verdana;">Comparison of hematological parameters of common thalassemia genotypes showed that the average value of MCH and MCV of -</span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;">3.7/-</span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;">4.2 type in Li n
作者
Junjie Hu
Xinping Chen
Xiaojuan Li
Weihua Xu
Shengmiao Fu
Junjie Hu;Xinping Chen;Xiaojuan Li;Weihua Xu;Shengmiao Fu(Department of Central Laboratory, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Hainan Provincial Key Laboratory for Cell and Molecular Genetic Translational Medicine, Haikou, China)
