摘要
Background: Radiotherapy is one of the main therapeutic strategies used in cervical cancer. The first radiotherapy services in Cameroon have existed since 1987 and still treat by conventional radiation techniques. With the evolution of radiation techniques, acute, subacute, and late complications are minimized. Our study aimed to describe the profile of side effects in patients with uterine cervix cancer treated by conventional radiotherapy, still used in our services. Methods: This was a retrospective and descriptive study of the records of patients treated in the radiotherapy department of the Douala General Hospital from January 2015 to December 2019. Data concerning radiation-induced toxicities were collected using the CTCAE Version 4.0 classification. Data analysis was performed using SPSS version 20.0. Results: A total of 270 records were selected. The median age was 54 years. The mean total radiation dose was 55.9 ± 11.8 Gy and 71.1% of patients were treated for less than 8 weeks. We found a frequency of 66.7% of radio-induced lesions with 99% being acute. The main acute lesions encountered were radio dermatitis (40%), radiation cystitis (17.7%), and radiation proctitis (17.1%). As late lesions, we found one case of vaginal fibrosis (0.4%). Exclusive radiotherapy, classical fractionation, and total doses lower than 45 Gy seemed to decrease the toxicity linked to conventional radiotherapy. Conclusion: The frequency of side effects of radiotherapy for cervical cancer at the Douala General Hospital remains high. Early lesions are the most encountered but strategies should be put in place to better evaluate late lesions.
Background: Radiotherapy is one of the main therapeutic strategies used in cervical cancer. The first radiotherapy services in Cameroon have existed since 1987 and still treat by conventional radiation techniques. With the evolution of radiation techniques, acute, subacute, and late complications are minimized. Our study aimed to describe the profile of side effects in patients with uterine cervix cancer treated by conventional radiotherapy, still used in our services. Methods: This was a retrospective and descriptive study of the records of patients treated in the radiotherapy department of the Douala General Hospital from January 2015 to December 2019. Data concerning radiation-induced toxicities were collected using the CTCAE Version 4.0 classification. Data analysis was performed using SPSS version 20.0. Results: A total of 270 records were selected. The median age was 54 years. The mean total radiation dose was 55.9 ± 11.8 Gy and 71.1% of patients were treated for less than 8 weeks. We found a frequency of 66.7% of radio-induced lesions with 99% being acute. The main acute lesions encountered were radio dermatitis (40%), radiation cystitis (17.7%), and radiation proctitis (17.1%). As late lesions, we found one case of vaginal fibrosis (0.4%). Exclusive radiotherapy, classical fractionation, and total doses lower than 45 Gy seemed to decrease the toxicity linked to conventional radiotherapy. Conclusion: The frequency of side effects of radiotherapy for cervical cancer at the Douala General Hospital remains high. Early lesions are the most encountered but strategies should be put in place to better evaluate late lesions.
作者
Berthe Sabine Esson Mapoko
Anne Marthe Maison Mayeh
Ruth Rosine Meka’h Mapenya
Orel Kelvin Ndouandju Saha
Esther Dina Bell
Etienne Atenguena Okobalemba
Anne Sango
Romeo Talla
Ambroise Ntama
Sidonie Ananga
Albertine Eloundou
Martin Essomba Biwole
Odette Samba Ngano
Albert Mouelle Sone
Emilienne Guegang Goudjo
Berthe Sabine Esson Mapoko;Anne Marthe Maison Mayeh;Ruth Rosine Meka’h Mapenya;Orel Kelvin Ndouandju Saha;Esther Dina Bell;Etienne Atenguena Okobalemba;Anne Sango;Romeo Talla;Ambroise Ntama;Sidonie Ananga;Albertine Eloundou;Martin Essomba Biwole;Odette Samba Ngano;Albert Mouelle Sone;Emilienne Guegang Goudjo(Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon;Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon;Faculty of Health Sciences, University of Buea, Buea, Cameroon;Faculty of Science, University of Dschang, Dschang, Cameroon)
