摘要
With the aging of the global population, bone degenerative diseases (such as osteoporosis) have become a major threat to the health of the elderly. The immune system plays a key role in the regulation of bone homeostasis and bone aging. This review describes the role of the immune microenvironment, and myeloid cells in bone aging, and explores their mechanisms in the regulation of osteoblast and osteoclast function. Meanwhile, this study explored drug interventions targeting myeloid cells in order to provide a new perspective for clinical treatment. Through a comprehensive analysis of the interaction of immune cells and bone metabolism, studies show the central role of the immune system in bone aging-related diseases and show promise for novel immunomodulatory therapies.
With the aging of the global population, bone degenerative diseases (such as osteoporosis) have become a major threat to the health of the elderly. The immune system plays a key role in the regulation of bone homeostasis and bone aging. This review describes the role of the immune microenvironment, and myeloid cells in bone aging, and explores their mechanisms in the regulation of osteoblast and osteoclast function. Meanwhile, this study explored drug interventions targeting myeloid cells in order to provide a new perspective for clinical treatment. Through a comprehensive analysis of the interaction of immune cells and bone metabolism, studies show the central role of the immune system in bone aging-related diseases and show promise for novel immunomodulatory therapies.
作者
Xianqi Qin
Wujia Yang
Luo Dong
Luchang Chen
Jihua Wei
Xianqi Qin;Wujia Yang;Luo Dong;Luchang Chen;Jihua Wei(Graduate School, Youjiang Medical University for Nationalities, Baise, China;Department of Sports Medicine, Baidong Hospital Affiliated to Youjiang Medical University for Nationalities, Baise, China)
