摘要
Epidermolysis bullosa (EB) is an inherited connective tissue disease causing blisters in the skin and mucosal membranes. In severe cases, EB may be associated with renal damage through several mechanisms, mainly immunological ones. The present case described a young male with dystrophic recessive EB who developed an advanced chronic renal damage secondary to tubulointerstitial nephritis that was demonstrated by a renal biopsy. Unpublished previously, this complication should be considered among the possible causes of renal damage in EB. Also it is recommended a protocoled surveillance of renal and urinary tract complications in children with EB.
Epidermolysis bullosa (EB) is an inherited connective tissue disease causing blisters in the skin and mucosal membranes. In severe cases, EB may be associated with renal damage through several mechanisms, mainly immunological ones. The present case described a young male with dystrophic recessive EB who developed an advanced chronic renal damage secondary to tubulointerstitial nephritis that was demonstrated by a renal biopsy. Unpublished previously, this complication should be considered among the possible causes of renal damage in EB. Also it is recommended a protocoled surveillance of renal and urinary tract complications in children with EB.
作者
Felipe Cavagnaro
María Joao Yubero
Marcela Valenzuela
Francis Palisson
Felipe Cavagnaro;María Joao Yubero;Marcela Valenzuela;Francis Palisson(Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile;Clínica Alemana de Santiago, Santiago, Chile;Fundación DEBRA-Chile, Santiago, Chile;Unidad de Nefrología Pediátrica, Hospital Guillermo Grant Benavente, Concepción, Chile)
