摘要
孕妇在围产期经历了一系列的生理和心理变化,这些变化可能导致下丘脑–垂体–肾上腺轴的激活和功能紊乱;皮质醇因能反映下丘脑–垂体–肾上腺轴功能,成为探索围产期抑郁症与下丘脑–垂体–肾上腺轴关系的重要生物标记物,因此,可通过探索皮质醇在围产期抑郁症状病因和病理生理学中的具体作用为其早期识别和疗效预测提供依据。本文就下丘脑–垂体–肾上腺轴与围产期抑郁症状的研究进展进行综述,旨在为国内相关研究设计和实施提供帮助。
Pregnant women undergo a series of physiological and psychological changes during the perinatal period, which may lead to the activation and dysfunction of the hypothalamic-pituitary-adrenal axis. Since cortisol can reflect the function of the hypothalamic-pituitary-adrenal axis, it has become an important biomarker to explore the relationship between perinatal depression and the hypothalamic-pituitary-adrenal axis. Therefore, exploring the specific role of cortisol in the etiology and pathophysiology of perinatal depression symptoms can provide a basis for its early recognition and curative effect prediction. This article reviews the research progress of hypothalamic-pituitary-adrenal axis and perinatal depressive symptoms, in order to provide help for domestic research design and implementation.
出处
《护理学》
2024年第5期534-539,共6页
Nursing Science
