摘要
胃饥饿素是一种主要由胃内分泌细胞分泌的肽类激素,在胃肠道调节过程中具有重要作用。在基础研究方面,研究者们发现,胃饥饿素可通过刺激中枢神经系统增加人体食欲和食物的摄入量,也可直接作用于胃肠道平滑肌细胞增加胃肠蠕动的频率和幅度,同时相关研究发现其与胃肠道肿瘤的发病也存在一定联系。在临床应用方面,目前胃饥饿素被用于胃肠道手术术后、胃肠动力障碍及胃肠道肿瘤患者的治疗。本文从胃饥饿素的基础研究到临床应用展开讨论,综述了胃饥饿素对胃肠功能的影响,期望为胃肠道疾病的诊断和治疗提供新的思路和方法。
Ghrelin is a peptide hormone mainly secreted by gastric endocrine cells and plays an important role in the regulation of the gastrointestinal tract. In terms of basic research, researchers have found that ghrelin can increase human appetite and food intake by stimulating the central nervous system, and can also directly act on gastrointestinal smooth muscle cells to increase the frequency and amplitude of gastrointestinal peristalsis, and at the same time, studies have found that it is also associated with the incidence of gastrointestinal tumors system. In terms of clinical application, ghrelin is currently used in the treatment of patients with gastrointestinal motility disorders and gastrointestinal tumors after gastrointestinal surgery. In this paper, we discuss the effects of ghrelin on gastrointestinal function from the basic research to clinical application, hoping to provide new ideas and methods for the diagnosis and treatment of gastrointestinal diseases.
出处
《临床个性化医学》
2024年第2期285-292,共8页
Journal of Clinical Personalized Medicine
