摘要
瞬时受体电位(TRP)通道属于一个大而多样的整合蛋白家族,作为热、化学和机械刺激的细胞传感器出现,并且是Ca2+信号的主要贡献者,在多种生理和病理过程中发挥重要作用。TRP通道与许多疾病有关,包括了众多编码TRP通道的基因缺陷引起的遗传性疾病(TRP通道病)。本文主要对TRP通道与相应遗传性疾病进行综述。
Transient receptor potential (TRP) channels belong to a large and diverse family of integrins, which appear as cellular sensors for thermal, chemical and mechanical stimulation, and are the main contributors to Ca2+ signals, playing an important role in a variety of physiological and pathological processes. TRP channel is related to many diseases, including hereditary diseases caused by many genetic defects encoding TRP channel (TRP channel disease). This article mainly reviews the TRP channels and related hereditary diseases.
出处
《生物医学》
CAS
2023年第2期282-286,共5页
Hans Journal of Biomedicine
