摘要
气喘为气管道的慢性发炎性疾病,急性发作严重时可能会造成呼吸衰竭,甚至导致生命危险。本篇研究目的为评估自国人体内筛选出之乳双岐杆菌GKK2改善OVA诱导之小鼠过敏情形及有效调节相关过敏因子。实验将Balb/c小鼠分为四组:生理食盐水组、OVA诱导气喘组、OVA诱导小鼠给予GKK2-100组(0.123 mg/day/kg)及OVA诱导小鼠给予GKK2-300组(0.41 mg/day/kg)。实验结果显示,OVA致敏小鼠经给予乳双岐杆菌GKK2低高两剂量组后,其呼吸道阻力、嗜酸性球(eosinophil)及OVA特异性IgE皆较OVA诱导气喘小鼠组别显著降低许多。在IFN- γ及IgG2a方面,给予乳双岐杆菌GKK2,则能有效增加致敏小鼠体内IFN- γ及IgG2a的含量,降低过敏反应。
Asthma is a chronic bronchitis that can cause respiratoryfailure and even lead to life-threatening in severe conditions.The presentstudy is to evaluate Bifidobacteriumlactis GKK2 ability in improving allergic problems and regulating relatedallergic factors in a mouse model of OVA-allergic asthma.Balb/c mice weredivided into four groups as follows:control group,OVA-allergic asthma group,OVA-allergic asthma with GKK2-100 group(0.123 mg/day/kg)and OVA-allergicasthma with GKK2-300 group(0.41 mg/day/kg).Results showed that after OVA-allergicasthma mice were given both doses of B.lactis GKK2,their airway resistance,eosinophil,and OVA-specific IgE weresignificantly lower than those of OVA-induced asthmatic mice.In the IFN-γand IgG2a,administration of B.lactis GKK2 can also effectivelyincrease the content of IFN-γand IgG2a in OVA-induced asthmatic mice and reduce allergic reactions.
出处
《生物医学》
CAS
2019年第2期70-80,共11页
Hans Journal of Biomedicine
