摘要
前列腺癌是男性最常见的泌尿生殖系统肿瘤,近年来与肥胖的发病率同步上升,引发关注。肥胖增加前列腺癌患者疾病发展、复发风险,加剧治疗相关不良反应,加速转移和激素抵抗,提高全因和特异性死亡率。尽管肥胖与前列腺癌的关联复杂,目前暂无定论,但多项研究指向肥胖对晚期前列腺癌的负面影响。肥胖可能通过胰岛素和胰岛素生长因子途径、性激素浓度、脂肪因子信号和炎症反应等途径与前列腺癌发生联系,但具体机制尚未明确。本文综述了肥胖与前列腺癌的关联及作用机制的研究进展。
Prostate cancer is the most common tumor of the male urogenital system. In recent years, the incidence of prostate cancer and obesity has increased synchronously, which has attracted attention. Obesity increases the risk of disease progression and recurrence in prostate cancer patients, aggravates adverse reactions related to treatment, accelerates metastasis and hormone resistance, and increases all-cause and specific mortality. Although the association between obesity and prostate cancer is complex and there is no final conclusion at present, many studies point to the negative impact of obesity on advanced prostate cancer. Obesity may be associated with prostate cancer through insulin and insulin growth factor pathways, sex hormone concentrations, adipokines signaling, and inflammatory reactions, but the specific mechanism is not yet clear. This article reviews the research progress on the association and mechanism between obesity and prostate cancer.
出处
《临床医学进展》
2024年第4期1941-1946,共6页
Advances in Clinical Medicine
