摘要
皮肤作为人体最大的器官,能够直观地反映机体整体的衰老水平。皮肤衰老可分为内源性衰老和外源性衰老,其细胞水平的主要表现是真皮层内成纤维细胞的老化,而其中ROS发挥着关键作用。ROS引起细胞老化的主要机制包括DNA损伤、线粒体氧化损伤、促炎细胞因子水平升高以及ECM的降解。在本综述中,将重点探讨皮肤衰老的特征、ROS的生成以及ROS导致皮肤老化的详细机制。
As the body’s largest organ, the skin provides a visual reflection of the overall aging status of the organism. Skin aging can be categorized into intrinsic aging and extrinsic aging, with the primary cellular manifestation occurring in the aging of dermal fibroblasts. In this process, ROS play a crucial role. The major mechanisms through which ROS induces cellular aging include DNA damage, mitochondrial oxidative stress, elevated levels of pro-inflammatory cytokines, and degradation of the ECM. This review focuses on elucidating the characteristics of skin aging, the generation of ROS, and the detailed mechanisms by which ROS contributes to skin aging.
出处
《临床医学进展》
2024年第4期1258-1262,共5页
Advances in Clinical Medicine
