摘要
骨质疏松症(Osteoporosis, OP)是一种常见的老年性骨病,由于骨的形成和吸收之间的平衡被破坏导致损伤骨的微观结构,最终骨脆性增加从而造成骨折风险上升和骨折率增加。骨骼的吸收与形成与骨骼代谢的动态和平衡息息相关,可通过不同的方式来影响骨骼代谢的动态和平衡进而影响骨骼重建。在其涉及的机制中,骨代谢和信号通路是紧密相连的,它们都对骨质疏松症做出了重要贡献。为了进一步治疗骨质疏松症,在本文中探究了与骨代谢有关的信号通路的研究,重点是OPG/RANKL/RANK、Wnt/β-catenin和组蛋白酶K信号通路,以及相关的靶点和抗骨质疏松症药物。
Osteoporosis (OP) is a common bone disease of old age, due to the disruption of the balance between bone formation and resorption leading to damage to the microstructure of the bone, and ultimately an increase in bone brittleness resulting in an increased risk of fracture and an increased fracture rate. Bone resorption and formation are closely related to the dynamics and balance of bone metabolism, which can be influenced in different ways to affect bone reconstruction. Among the mechanisms involved, bone metabolism and signaling pathways are closely linked, and both of them make important contributions to osteoporosis. To further the treatment of osteoporosis, the study of signaling pathways related to bone metabolism is explored in this paper, focusing on the OPG/RANKL/RANK, Wnt/β-catenin and histone enzyme K signaling pathways, as well as related targets and anti-osteoporosis drugs.
出处
《临床医学进展》
2024年第3期1853-1858,共6页
Advances in Clinical Medicine
