摘要
胎膜早破(premature rupture of membranes, PROM)是一种常见的妊娠期疾病,可诱发母体早产、胎盘早剥和新生儿呼吸窘迫综合征、绒毛膜羊膜炎等并发症。沉默信息调节因子1 (sirtuin1, SIRT1)是首个在哺乳动物体内发现的沉默信息调节因子家族成员,可抑制子宫收缩或通过NF-κB通路介导MMPs表达下降抑制PROM的发生。基质金属蛋白酶(atrix metallo proteinases, MMPs)是一种内源性Ca2+、Zn2+依赖性蛋白酶家族,其表达升高可通过降解细胞外基质导致PROM发生,已知在PROM发生过程中起关键作用的MMPs为MMP-2、3、9等。现就SIRT1、MMPs与胎膜早破的相关性进行综述,以期对胎膜早破的发生机制有进一步认识。
Premature rupture of fetal membrane is a common pregnancy disease, which can induce premature birth, placental abruption, neonatal respiratory distress syndrome, chorioamnitis and other com-plications. Silencing message regulator 1 is the first member of a family of silencing message regu-lators identified in mammals that inhibits uterine contraction or PROM through the NF-κB pathway that mediates a decline in MMPs expression. Matrix metalloproteinases are a family of endogenous Ca2+ and Zn2+ dependent proteinases whose increased expression can lead to PROM generation through degradation of extracellular matrix. MMP-2, 3, 9 and other MMPs are known to play a key role in PROM generation. This article reviews the correlation between SIRT1, MMPs and premature rupture of membranes in order to further understand the mechanism of premature rupture of membranes.
出处
《临床医学进展》
2023年第12期18969-18975,共7页
Advances in Clinical Medicine
