摘要
扩张型心肌病(dilated cardiomyopathy, DCM)是引起心力衰竭(心衰)、心律失常和猝死的常见疾病之一。研究证实基因缺陷、免疫因素和病毒感染是诱发DCM的三个主要病因。异常激活的免疫反应作用下产生的自身抗体在DCM发生发展中起着至关重要的作用,可作为DCM的免疫标记物,有助于免疫性DCM诊断及后续治疗靶点而备受关注。然而,DCM相关自身抗体产生的免疫反应机制及治疗措施仍待进一步研究。本文针对DCM相关的几种抗心肌抗体及治疗进展做一综述。
The DCM (dilated cardiomyopathy, DCM) is a cause of heart failure (HF), cardiac arrhythmia, and sudden death of one of the common diseases. Studies have confirmed that gene defects, immune factors and virus infection are the three main causes of DCM. Autoantibodies produced by abnor-mally activated immune responses play a crucial role in the occurrence and development of DCM, and can be used as immune markers of DCM, which is helpful for the diagnosis of immune DCM and the target of subsequent treatment. However, the immune response mechanism and therapeutic measures of DCM-related autoantibodies still need to be further studied. In this paper, several an-ti-myocardial antibodies related to DCM were reviewed.
出处
《临床医学进展》
2023年第10期16623-16632,共10页
Advances in Clinical Medicine
