摘要
随着慢性肾脏病(chronic kidney disease, CKD)发病率的逐年增加,CKD已经成为全球性健康挑战,严重影响患者的生活质量及预期寿命。同型半胱氨酸(Homocysteine, Hcy)是日常饮食中甲硫氨酸代谢的中间产物,其代谢平衡受叶酸、B族维生素等辅助因子及基因突变等因素的影响。在CKD患者中可以发现多数患者存在血Hcy水平的升高。高同型半胱氨酸氨酸血症(Hyperhomocysteinaemia, HHcy)近年来一直被认为是CKD患者的一个严重危险因素,同时也是心脑血管疾病(Cardiovascular disease, CVD)的独立危险因素,而CVD是终末期肾病(end-stage renal disease, ESRD)患者死亡的主要原因。合理补充B族维生素、叶酸是控制Hcy水平,预防其相关疾病的有效措施。随着关于Hcy、叶酸、B族维生素与CKD研究的逐渐深入,Hcy与CKD间的关系仍需要更多的研究进一步证实,而叶酸与B族维生素降低Hcy水平对降低CKD患者CVD风险的有效性也尚不明确。本文旨在对目前已发表的Hcy与CKD的相关研究进行综述,以期为CKD的治疗和预防提供参考。
With the increasing incidence of chronic kidney disease (CKD) year by year, CKD has become a glob-al health challenge, which seriously affects the quality of life and life expectancy of patients. Homo-cysteine (Hcy) is an intermediate product of methionine metabolism in daily diet. Its metabolic balance is affected by folic acid, B vitamins and other cofactors as well as gene mutations. Elevated Hcy levels can be found in most patients with CKD. Homocysteine acid hematic disease (Hyperho-mocysteinaemia, HHcy) in recent years has always been considered a significant risk factor in pa-tients with chronic kidney disease (CKD), as well as the independent risk factors of cardiovascular diseases (CVD). And CVD is the leading cause of death in patients with end-stage renal disease (ESRD). Reasonable supplement of B vitamins and folic acid is an effective measure to control the level of Hcy and prevent its related diseases. With the gradual deepening of studies on Hcy, folic acid, B vitamins and CKD, the relationship between Hcy and CKD still needs to be further confirmed by more studies, and the effectiveness of folic acid and B vitamins in reducing the risk of CVD in pa-tients with CKD is still unclear. This paper aims to review the published studies on Hcy and CKD, in order to provide reference for the treatment and prevention of CKD.
出处
《临床医学进展》
2023年第5期8502-8511,共10页
Advances in Clinical Medicine
