摘要
烟雾病(Moyamoya Disease)是一种极为少见的进行性脑血管疾病,是以颈内动脉末端及其主要分支进行性狭窄为主要表现,日语中的“moyamoya”一词的意思是“一股朦胧的烟雾”,指的是脑血管造影中侧支血管的特征性外观像一团烟雾。颈内动脉终末的进行性狭窄和闭塞是烟雾病病理的主要特征,并伴有侧支血管的形成。尽管进行了广泛的研究,但MMD的发病机制尚不清楚。慢性炎症是各种疾病的病理特征;炎症反应通过增殖引起内膜血管平滑肌细胞增生和新生血管通过内皮细胞增殖导致管腔狭窄和侧支形成。本文就烟雾病的病理学和IL-1β、VEGF、TGF-β1等细胞因子等作一综述和总结。
Moyamoya disease is an extremely rare progressive cerebrovascular disease that is characterized by progressive stenosis of the terminal internal carotid artery and its major branches. The Japanese word “moyamoya” means “a hazy smoke”, referring to the characteristic appearance of the collateral vessels as a cloud of smoke on cerebral angiography. Progressive stenosis and occlusion of the end of the internal carotid artery are the main features of Moyamoya Disease pathology, along with the formation of collateral vessels. Despite extensive studies, the pathogenesis of MMD is unknown. Chronic inflammation is a pathological feature of various diseases. The inflammatory response causes endothelial vascular smooth muscle cell proliferation through proliferation and neovascu-larization through endothelial cell proliferation leading to luminal stenosis and collateral branch formation. This article provides a review and summary of the pathology of Moyamoya Disease and cytokines such as IL-1β, VEGF, and TGF-β1.
出处
《临床医学进展》
2022年第8期7142-7148,共7页
Advances in Clinical Medicine
