摘要
ELABELA是最近发现的一种与心脏发育相关的肽,与APELIN共同受体为APLNR。近年来发现,ELABELA及其受体除在心血管疾病等方面具有生理调节作用外,其还在胚胎和心血管发育、子痫前期、妊娠期糖尿病及卵巢癌等方面,也具有重要的病理生理学功能,由ELABELA、Apelin及Apelin受体组成的ELA-Apelin-APJ系统(Apelinergic系统)广泛表达于机体不同器官组织,参与许多病理生理过程中。因此本文将简述ELABELA及其在子痫前期和妊娠期糖尿病的研究进展做一综述,以期为临床上治疗提供新的途径和方法。
ELABELA is a recently discovered peptide related to cardiac development, and its co-receptor with APELIN is APLNR. In recent years, ELABELA and its receptors have been found to have important pathophysiological functions in embryonic and cardiovascular development, preeclampsia, gesta-tional diabetes, and ovarian cancer, in addition to their physiological regulatory roles in cardiovas-cular diseases. The ELA-Apelin-APJ system (Apelinergic system) composed of ELABELA, Apelin and Apelin receptors is widely expressed in different organs and tissues of the body and participates in many pathophysiological processes. Therefore, this article will briefly describe ELABELA and its re-search progress in preeclampsia and gestational diabetes mellitus, in order to provide new ap-proaches and methods for clinical treatment.
出处
《临床医学进展》
2022年第5期4723-4728,共6页
Advances in Clinical Medicine
