摘要
基质金属蛋白酶(matrix metalloproteinases)是一组锌依赖性的酶家族,在调节人体生理过程和病理过程尤其恶性肿瘤中的地位日渐显著。经研究表明,降解细胞外基质、调节基因多态性、促进上皮间质转化、诱导黏附分子表达等是MMPs参与肿瘤细胞侵袭和转移的具体过程。同时,MMPs在作为肿瘤诊断标志物、癌症预后、药物靶点等方面为临床提供了一定依据。在本篇综述中,阐述了MMPs在恶性肿瘤中的相关表达、对肿瘤细胞的作用特点以及关于临床生存、预后等情况。在本篇综述中,阐述了MMPs在恶性肿瘤中的相关表达、对肿瘤细胞的作用特点以及关于临床生存、预后等情况。
Matrix metalloproteinases are a family of zinc-dependent enzymes, which play an increasingly prominent role in regulating human physiological and pathological processes, especially in malig-nant tumors. Studies have shown that MMPs are involved in the specific processes of tumor cell in-vasion and metastasis, such as degradation of extracellular matrix, regulation of gene polymor-phism, promotion of epithelial mesenchymal transformation, and induction of adhesion molecule expression. At the same time, MMPs as tumors diagnostic markers, cancer prognosis, drug targets and other aspects provide a certain basis for clinical. In this review, the relevant expression of MMPs in malignant tumors, the characteristics of its effects on tumors cell, as well as its clinical sur-vival and prognosis were described.
出处
《临床医学进展》
2022年第5期4355-4360,共6页
Advances in Clinical Medicine
