摘要
术后认知功能障碍(Postoperative Cognitive Dysfunction, POCD)是外科手术常见并发症之一,好发于老年骨科手术患者,尤其是老年髋部骨折患者。近年来研究发现,术后认知功能障碍患者存在明显的肠道菌群紊乱,提示肠道菌群在POCD发生发展中发挥重要作用。本文基于目前的有关基础实验及临床研究,对肠道菌群参与术后认知功能障碍发生发展途径及机制进行综述,以望对其科学研究和临床治疗提供新思路。
Postoperative cognitive dysfunction (POCD) is one of the common complications of surgery. It often occurs in elderly orthopaedic patients, especially elderly patients with hip fracture. Recent studies have found that patients with postoperative cognitive dysfunction have obvious intestinal flora disorder, suggesting that gut microbiota plays an important role in the occurrence and de-velopment of POCD. Based on the current basic experimental and clinical research, this paper summarizes the ways and mechanisms of gut microbiota involved in the occurrence and develop-ment of postoperative cognitive dysfunction, in order to provide new ideas for its scientific research and clinical treatment.
出处
《临床医学进展》
2022年第4期3542-3549,共8页
Advances in Clinical Medicine
