摘要
放射治疗是诊断后一半以上癌症患者的主要抗癌方式,与化学疗法相比,其具有局部肿瘤控制的优势,且系统性副作用相对较少。然而,放射治疗的疗效受到获得性肿瘤耐药性的限制,导致复发和转移的风险。自从免疫疗法在癌症治疗中出现以来,现在已经确定放疗与此类治疗的关联可以促进放射诱导的抗肿瘤免疫的出现。因此,这种组合近年来引起了科学界越来越大的兴趣,并正在大量临床前模型中进行研究,也在许多临床试验中付诸实践。在这篇综述中,我们旨在总结放射治疗与免疫系统之间的相互影响以及放射治疗与免疫治疗相结合对肿瘤治疗效果的影响。
Radiation therapy is the main anti-cancer method for more than half of the cancer patients after diagnosis, it has the advantage of local tumor control over chemotherapy and has relatively few systemic side effects. However, the efficacy of radiotherapy is limited by resistance to acquired tumors, leading to the risk of recurrence and metastasis. Since the advent of immunotherapy in cancer therapy, it has now been established that the association of radiation therapy with such treatments can promote the emergence of radiation-induced antitumor immunity. Therefore, this combination has attracted increasing interest in the scientific community in recent years and is being studied in a large number of preclinical models and also put into practice in many clinical trials. In this review, we aimed to summarize the inter effects between radiotherapy and the immune system and the impact of the combination of radiotherapy and immunotherapy on the effect of tumor therapy.
出处
《临床医学进展》
2022年第2期1014-1021,共8页
Advances in Clinical Medicine
