摘要
干性老年性黄斑变性早期可不表现出明显的视觉功能丧失,因而不易被重视,进展至晚期患者多因黄斑区视网膜地图样萎缩影响夜视力及中心视力而就医。目前主要治疗方法包括改善抗氧化应激损伤、减少有害物质蓄积、减少玻璃体疣形成、调节炎症及免疫反应、改善脉络膜灌注、以及神经保护剂、调节脂质代谢及中医中药治疗等。目前已有多项研究发现多个基因位点的突变与干性AMD有关,干细胞移植治疗萎缩型AMD是目前最有前景的治疗手段。
Atrophic age-related macular degeneration does not show obvious loss of visual function in the early stage, so it is not easy to be taken seriously. In the advanced stage, most of the patients suffered from macular area retinal map atrophy, which affected night vision and central vision. At present, the main treatment methods include improving the antioxidative stress injury, decreasing the accumulation of harmful substances, decreasing the formation of vitreous verruca, regulating inflammation and immune response, improving choroidal perfusion, as well as neuroprotective agents, regulating lipid metabolism and traditional Chinese medicine treatment. At present, many studies have found that mutations in multiple gene loci are related to dry AMD. Stem cell transplantation is the most promising treatment for atrophic AMD.
出处
《临床医学进展》
2020年第5期849-855,共7页
Advances in Clinical Medicine
基金
常州市科技项目(CJ20190012)。
