摘要
目的 观察加味五子衍宗颗粒治疗轻度认知障碍的临床疗效与安全性,并探讨其作用机制。方法 参考目前国际公认的轻度认知障碍(mild cognitive impairment,MCI)诊断标准,筛选出44例MCI患者,随机分为治疗组(22例)和对照组(22例)。治疗组服用加味五子衍宗颗粒,对照组服用银杏叶胶囊,服药3个月,观察用药前后记忆商(MQ)、血清中乙酰胆碱脂酶(AchE)、超氧化物歧化酶(SOD)活性,血清丙二醛(MDA)含量及白细胞线粒体DNA缺失率。结果 治疗后两组的MQ、血清SOD活性均较治疗前升高,而血清MDA含量、白细胞线粒体DNA缺失率和AchE水平较治疗前降低(P<0.01)。两组经统计学分析差异无显著性。两组均未发现明显的毒副作用。结论 加味五子衍宗颗粒和银杏叶胶囊均能有效改善MCI患者的记忆功能,其机理可能与降低AchE活性、改善自由基代谢、减少线粒体DNA氧化损伤有关。
To observe the clinical efficacy and safety of modified Wuzi Yanzong Granule (MWYG) in treating mild cognitive impairment (MCI), and to explore its mechanism. Methods Forty-four MCI patients were selected referring to the international recognized Peterson s criteria and randomly divided into two groups, the treated group treated with MWYG and the control group treated with Ginkgo leaf extraction, with the course of 3 months for both groups. Changes of memorial quotient (MQ), superoxide dismutase (SOD) activity , malondialdehyde (MDA) content, mitochondrial DNA (mtDNA) deletion rate and acetylcholinesterase (AchE) before and after treatment were observed. Results After treatment, levels of MQ, serum SOD activity increased and serum MDA content, mtDNA deletion rate and AchE decreased in both groups (P<0.01), but the difference between the two groups was insignificant. No adverse reaction was found in two groups. Conclusion Both MWYG and Ginkgo leaf capsule can effectively improve the memorial function of patients with MCI, the therapeutic mechanism is possibly related with the actions in reducing AchE activity, improving free radical metabolism, and alleviating mitochondrial DNA oxidation damage.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2004年第5期392-395,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
北京大学985资助项目
