摘要
目的 :观察三七叶提取物对大鼠大脑中动脉缺血模型的影响。方法 :通过栓线法造成大脑中动脉缺血 ,观察三七叶提取物对缺血大鼠的行为状态、脑缺血面积、脑组织形态学的作用。结果 :三七叶提取物 42 .0、2 1.0、10 .5mg/kg能明显改善大鼠脑缺血后的行为状态 ,缩小缺血范围 ,降低缺血程度 。
Objective: To study the protective effect of PPGLE on the cerebral ischemia injury. Method: Employ focal cerebral ischemia model via the thread occluding method to explore the protective effects of PPGLE on the score of neurological deficits, the rate of cerebral infarction and histomorphology of cerebral ischemia rats. Results: PPGLE was perfusied to the stomach of rats by 42.0, 21.0 and 10.5mg/kg respectively, which could distinctly improve the score of neurological deficits of cerebral ischemia rats and reduce the rates of cerebral infarction rats and the level of cerebral ischmia injury. It is also able to improve the cerebral textus of pathological change.
出处
《中药药理与临床》
CAS
CSCD
2004年第2期17-18,共2页
Pharmacology and Clinics of Chinese Materia Medica
关键词
三七叶提取物
大鼠
脑缺血
动物模型
药理学
Panax Pseudo ginseng leaves extract
total saponin
total flavone
focal cerebral ischemia
