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抗CCP抗体在类风湿关节炎诊断中的意义 被引量:7

The diagnostic value of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis
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摘要 目的 探讨抗环瓜氨酸肽 (CCP)抗体对类风湿关节炎 (RA)的诊断意义 ,并了解其与抗核周因子 (APF)及IgM型类风湿因子 (RF)之间的相关性。 方法 ELISA法检测 3 3例RA、2 8例非RA病例及 2 6例正常人血清的抗CCP抗体。结果  3 3例RA病人中 ,抗CCP抗体阳性 18例 ,抗CCP抗体对RA诊断的敏感性为 75 .8%;对照组阳性率7.4%( 4 / 5 4) ,特异性为 92 .6%。 3 3例RA中抗CCP抗体与APF同时阳性 18例 ,同时阴性 4例 ,两者一致率为 66.7%;与RF同时阳性 2 1例 ,同时阴性 4例 ,一致率为 75 .8%。抗CCP抗体与APF及RF抗体的相关性无统计学意义。结论 抗CCP抗体是一种新的对RA有较高诊断价值的血清学标记物。 Objective To explore the diagnostic value of anti-cyclic citrullinated peptide antibody (anti-CCP) in patients with rheumatoid arthritis (RA), and association of anti-CCP with antiperinuclear factor (APF) and IgM rheumatoid factors (RF). Methods Anti-CCP were tested by an enzyme linked immunosorbent assay (ELISA) in serum samples from 33 patients with RA, 28 non-RA controls with various rheumatic disease, and 26 healthy individuals. Results The diagnostic sensitivity of anti-CCP for RA was 75.8%(18/33), and specificity was 92.6%. Out of 25 anti-CCP positive sera, 18 were positive for APF and 21 were positive for IgM-RF, and 8 anti-CCP negative sera, 4 were negative for both APF and IgM-RF. No significantly association was found between anti-CCP and APF or IgM-RF. Conclusion Anti-CCP is a valuable diagnostic tool and a useful additional marker for RA, The detection of anti-CCP is useful for the diagnosis of RA, especially combined with APF and IgM-RF.
出处 《安徽医学》 2004年第3期171-173,共3页 Anhui Medical Journal
基金 安徽省自然科学基金资助项目 (编号 :0 30 4 371 3)
关键词 抗CCP抗体 类风湿关节炎 诊断 抗核周因子 Arthritis rheumatoid Anti-citrulllinated peptide antibody Antiperinuclear factor Enzyme-linked immunosorbent assay
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