摘要
目的研究降香挥发油固体脂质纳米粒制备中的主要影响因素。方法分别采用高压乳匀法和熔融 超声法制备了降香挥发油固体脂质纳米粒混悬液。以单因素考察和正交设计法研究制备工艺中影响降香挥发油固体脂质纳米粒质量的主要因素 ,筛选出较理想的处方和工艺。结果所得纳米粒为圆整的类球形实体粒子 ,表面光滑 ,平均粒径为 4 0 0nm和 34 5nm ,含药量为 72 11%和71 5 4 % ,包封率为 91 2 7%和 92 36 %。结论采用熔融 超声法制备降香挥发油固体脂质纳米粒实用性更强。
Objective To prepare solid lipid nanoparticals containing volatile oil of Lignum Dalbergia odoriferae by the high pressure homoenizer mothod and hot-dispersion technique respectively.Method The main factor affecting solid lipid nanopaticals containing volatile oil of Lignum Dalbergia odoriferae quality in the preparation technics was researched by the single factor exploration and orthogonal design.The satisfactory formulation was selected.Results The results revealing the nanoparticles were spherelike with the mean size of 40.0 nm and 34.5 nm,the content of dispersion was 72.1% and 71.54%.Entrapment efficiency of nanoparticles was 91.27% and 92.36%.Conclusion The hot-dispersion technique on the preparation of solid lipid nanoparticles containning volatile oil of Lignum Dalbergia odoriferae has great practical use.
出处
《沈阳药科大学学报》
CAS
CSCD
2004年第4期257-260,296,共5页
Journal of Shenyang Pharmaceutical University
关键词
降香
挥发油
固体脂质纳米粒
制备工艺
Lignum Dalbergia odoriferae
volatile oil
solid lipid nanoparticle
preparation technics
