摘要
目的:分析非小细胞肺癌(NSCLC)及癌周正常肺组织p16蛋白表达情况。方法:运用免疫组化方法检测40例肺癌标本及周围正常肺组织中p16蛋白的表达情况。结果:肺癌组织p16蛋白表达降低率(65％)与其周围正常肺组织(20％)有明显差异(P<0.01)。非小细胞肺癌各亚型之间p16蛋白表达降低率没有差异(P>0.01)。低分化鳞癌p16蛋白表达降低率(100％)明显高于高中分化鳞癌(63％,P<0.01),低分化腺癌p16蛋白表达降低率(100％)亦明显高于高中分化腺癌(33％,P<0.01)。结论:p16蛋白在非小细胞肺癌组织中的表达明显低于正常肺组织。
Objective: To study p16 expression in non-small cell lung cancers(NSCLC). Methods;40 NSCLC and its surrounding normal lung tissure were chosed to study the p!6 expression with the method of immunohistochemistry. Results: Obviouse difference of p16 expression was found between NSCLC and normal lung tissure ( P < 0. 01). There was no difference of p16 expression between subtypes of NSCLC(P > 0. 01). The p16 expression of Low differenciate squamouse cell Ca was much lower than that of high and middle ones(P <0. 01 ) , the p16 expression of Low differenciate adenocarcinoma was much lower than that of high and middle ones(P <0. 01 ). Conclusion: The p16 protein expression of NSCLC was much lower than that of normal lung tissure.
出处
《军医进修学院学报》
CAS
2004年第2期124-125,共2页
Academic Journal of Pla Postgraduate Medical School
