摘要
目的研究我国结直肠癌发病模式近年来的变化。方法收集发表于1980年至1999年CJCR收录的中国核心期刊上发表的21篇中、英文文章。本研究总计10201例结直肠癌患者,根据发病时间,将他们分为80年代(1980～1989年)和90年代(1990～1999年)两组。结果80年代组有3420例患者,而90年代组有6781例患者。男、女比例80年代(1.50∶1)与90年代(1.26∶1)比较,差异有显著性意义(P<0.05)。原发肿瘤最常见的部位两组均在直肠,但直肠癌所占比例显著下降,横结肠和升结肠癌所占比例均显著升高,与之相比差异有显著性意义(P<0.001)。近侧结肠癌的比例增加(10.9%升至15.2%,P<0.001)。90年代组的DukesB期患者比例高于80年代组,而DukesD期患者所占比例明显减少(P<0.001)。结直肠腺癌的比例增高。结论中国结直肠癌的发病模式近年来变化很大,女性患者比例升高,发病部位逐渐右移。
Objective To investigate the changing patterns of colorectal cancer development in China during the recent two decades. Methods Data from twenty one Chinese articles published from 1980 to 1999 were collected to analyze the time trend of colorectal cancer according to the patientsage at diagnosis, sex, the site of the tumor, stage and the pathology. Results From 1980s to 1990s, the mean age of the colorectal cancer patients increased. The percentage of the female patients rose significantly(P< 0.05). The distribution of CRC showed a predominance of rectal cancer during the two periods. However, the proportion of proximal colon cancer (including transverse and ascending colon cancer) increased significantly, while the proportion of rectal caner decreased(P< 0.001). In the 1990s, the proportion of the patients with Dukes B stage was higher, while that with Dukes D stage was lower than those in 1980s(P< 0.001). The proportion of adenocarcinoma increased but the mucinous adenocarcinoma decreased during the two decades. Conclusion The pattern of colorectal cancer development in China changes obviously,especially, a proximal shift due to the increasing proportion of ascending and transverse colon occurres.
出处
《中华胃肠外科杂志》
CAS
2004年第3期214-217,共4页
Chinese Journal of Gastrointestinal Surgery
