摘要
目的 研究格列美脲的小肠吸收方式。方法 利用大鼠在体肠吸收模型 ,以高效液相色谱法测定格列美脲在小肠吸收速率。结果 在低、高 2种给药剂量下 ,格列美脲在大鼠小肠的平均吸收速率分别为 0 .2 3 3 6h-1 、0 .2 178h-1 。
Objective To study the small intestinal absorption patterns of glimepiride in rats. Methods A rat model of small intestinal absorption in vivo was employed in this study. The small intestinal absorption rate of glimepiride was detected by high performance liquid chromatography. Results At the low and high concentrations of glimepiride, the average small intestinal absorption rates were 0.233 6 h -1 and 0.217 8 h -1 , respectively. Conclusion The small intestinal absorption pattern of glimepiride might be passive diffusion.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2004年第10期886-888,共3页
Journal of Third Military Medical University
关键词
格列美脲
小肠吸收
被动扩散
高效液相色谱法
glimepiride
small intestinal absorption
passive diffusion
high performance liquid chromatography
