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两种药物对EDTA依赖性血小板聚集的抑制作用 被引量:45

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摘要 目的 探讨噻氯匹啶、氟化钠在体外对EDTA依赖性血小板聚集的抑制作用。方法 采用CoulterSTKS血液分析仪分析不同浓度的噻氯匹啶或氟化钠在体外对EDTA性血小板聚集的影响。结果 两种药物对EDTA依赖性血小板聚集抑制作用不同 ,氟化钠能显著地抑制EDTA依赖性血小板聚集 ,3h内其血小板计数与手工法相比无显著差异 (P >0 .0 5 ) ;噻氯匹啶也有一定的抑制作用 ,2h内其血小板计数与手工法相比无显著差异 (P >0 .0 5 ) ,但NaF使MPV显著增加 (P <0 .0 5 )。结论 噻氯匹啶和氟化钠对EDTA依赖性血小板聚集均有很好的抑制作用 ,但氟化钠作用更强 ,适用于临床上EDTA依赖性血小板聚集者的测定 ,但影响MPV。
出处 《临床检验杂志》 CAS CSCD 北大核心 2004年第3期198-199,共2页 Chinese Journal of Clinical Laboratory Science
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