摘要
脉络膜新生血管(choroidalneovascularization,CNV)是发达国家老年人视力损害的主要原因之一,发生机制尚不完全清楚。正常情况下,血管生成因子和抑制因子在体内处于动态平衡状态。任何原因引起血管生成因子相对或绝对增多就会导致新生血管生成。已有许多关于血管生成因子的研究报道,如碱性成纤维细胞生长因子(basicfibroblastgrowthfactor,bFGF)、转化生长因子(transforminggrowthfactor,TGF)和血管内皮生长因子(vascularendothe-lialgrowthfactor,VEGF)等。近年陆续发现一些内源性血管抑制因子,如色素上皮衍生因子、可溶性血管内皮生长因子受体阻断剂、金属蛋白酶组织抑制因子、凝血酶敏感蛋白、软骨源性抑制因子、血管抑素和内皮抑素等。内源性血管抑制因子的抗新生血管作用为临床防治CNV相关疾病带来了新希望。
Choroidal neovascularization (CNV) is a major cause of vision loss in the elderly in developed world, while much is unclear about the underlying pathogenesis of CNV. Normally, the vasculature is quiescent possibly because of a balance between pro- and anti-angiogenic factors. It is believed that the angiogenic process will be initiated when the balance switches to the angiogenic side. Various growth factors, including basic fibroblast growth factor, transforming growth factor-β, and vascular endothelial growth factor, have been reported to be involved in these processes. Recently, several endogenous inhibitors of angiogenesis have also been identified. Antiangiogenic treatments could be helpful for the prevention and treatment of the CNV-related diseases. We review in this paper the features and CNV-related studies of some common endogenous inhibitors of angiogenesis, such as pigment epithelium-derived factor, soluble fms-like tyrosine kinase-1, tissue inhibitors of matrix metalloproteinase, thrombospondin-1, chondromodulin-1, angiostatin and endostatin.·
出处
《国际眼科杂志》
CAS
2004年第2期307-311,共5页
International Eye Science
基金
中国国家自然科学基金资助项目(No.30371516)
中国西安第四军医大学科技创新工程项目(No.CX02A021)
关键词
内源性血管抑制因子
研究进展
脉络膜
新生血管
视力损害
老年人
choroidal neovascularization
pigment epithelium-derived factor
soluble VEGF receptor inhibitor
tissue inhibitors of matrix metalloproteinase
thrombospondin-1
chondromodulin-1
angiostatin
endostatin
