摘要
目的 估算1 31 I 肿瘤细胞核人鼠嵌合单克隆抗体 (chTNT)肿瘤治疗中肿瘤和主要器官内照射吸收剂量。方法 9例肿瘤患者 ,单次静脉注射1 31 I chTNT按体重 (2 9 6± 3 7)MBq kg后测量各时间点血、尿样放射性 ,并采用连续 (配对 )显像结合CT扣除周围组织本底的方法估算各时间点全身、肿瘤及主要器官放射性 ;将原始数据转换为百分注射剂量 (%ID) ,用一室或二室模型拟合时间 放射性曲线 ,求单位累积活度 ,采用医用内照射照射吸收剂量 (MIRD)方法将其输入Mirdose 3软件 ,求得全身、肿瘤和各主要器官的平均总吸收剂量。结果 肿瘤平均总吸收剂量为 (8 2 8± 2 6 5 )Gy ,瘤 非瘤比值为 3 95± 1 5 5。结论 该注射剂量难以满足抑制肿瘤生长的要求。为姑息性抑制肿瘤生长 ,有必要多次重复给药。
Objective To assess the irradiated absorbtive dose of tumor and main critical organs chimeric tumor necrotic treatment (chTNT). Methods In 9 lung cancer patients a single intravenous dose of 131 I-chTNT (29.6±3.7) MBq/kg was administered. Blood samples were drawn at different time intervals and urine was collected for up to one week. Tissue distribution was followed for up to one week by gamma camera imaging. The geometric mean of the anterior and posterior counts was obtained from selected regions of interest (ROIs) to determine activity within the critical organs after being subtracted the background activity. Counts from thyroid were obtained from anterior images only. A background region was drawn below the thyroid gland to subtract underlying activity in the neck blood vessels. The geometric mean of the counts in the whole body scintigram at 0.5 h after injection was corrected for radioactive decay from the time of injection,this value being taken as 100%ID. The residence times for each critical organ and the remainder of the body were computed by dividing the area under their %ID/h curves by the 100%ID value. Absorbed doses to the whole body and to normal organ were computed from the residence time according to the MIRD scheme using Mirdose-3 software. Absorbed doses to tumor tissues were estimated using the same approach taken for normal organs. S-factors for tumors were estimated by comparison with normal organs of similar mass and position in the body. Results Mean serum disappearance half time values for 131 I-chTNT were α (4.9±9.4) h,β (61.7±21.2) h;and whole body,(99±10)h. Mean urine biological clearance half time values was (90±10) h. The absorbed dose of tumor was (8.28±2.65) Gy,the tumor-to-nontumor ratio was 3.95±1.55,while the absorbed dose of marrow was 0.44～0.73 Gy,thyroid was 0 47～23.09 Gy,ovaries was 0.50～0.77 Gy,testicles was 0.38～0.58 Gy,kidneys was 1.71～4.55 Gy,liver was 1.18～2.63 Gy,and lungs was 1.55～2.74 Gy. Conclusions Single intravenous dose of
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2004年第2期113-116,共4页
Chinese Journal of Nuclear Medicine
