摘要
目的 探讨99Tcm sandostatin生长抑素受体显像对肺癌的诊断价值。方法 35例肺部肿瘤患者静脉注射99Tcm sandostatin (991 6± 187 5 9)MBq后行平面及胸部断层SPECT显像 ,重建后获得发射 透射图像及融合图像。勾画感兴趣区 ,计算肿瘤和对侧正常肺组织的放射性比值 (T N)。所有病灶均经病理检查及 (或 )其他检查证实。 5例孤立性肺结节 (SPN)行1 8F 脱氧葡萄糖 (FDG)符合线路显像 ,1例小细胞肺癌 (SCLC)治疗前后均行99Tcm sandostatin显像。 15例受检者于99Tcm sandostatin显像后 1周内行全身骨显像。结果 99Tcm sandostatin显像诊断肺癌的灵敏度、特异性和准确性分别为 93 3%、5 5例和 94 3%。 2例鳞癌99Tcm sandostatin显像假阴性。 4例SCLC99Tcm sandostatin显像发现胸膜异常放射性浓聚区 ,病理检查证实为胸膜转移。15例骨显像中 12例发现骨转移 ,99Tcm san dostatin仅发现 5例骨转移。SCLC、非小细胞肺癌 (NSCLC)T N分别为 3 4 3± 0 6 6、2 2 4± 0 31,差异有显著性 (t=4 0 72 ,P <0 0 0 1)。SCLC对99Tcm sandostatin的摄取明显高于NSCLC。结论 99Tcm san dostatin生长抑素受体显像无创、安全、经济 ,对肺癌有较好的诊断价值。
Objective To determine the efficacy of noninvasive 99 Tc m-sandostatin imaging for lung cancer. Methods 35 consecutive patients,including 13 small cell lung cancer (SCLC),17 none small cell lung cancer (NSCLC) and 5 single pulmonary nodes (SPN) (9 female,26 male,mean age: 62 y) were studied. Planar images were obtained after injection of (991.6±187.59) MBq 99 Tc m-sandostatin. Additional SPECT images of the chest were performed at 4～6 h post injection. Fluorodeoxyglucose (FDG) metabolism imaging were also performed in 5 SPN. Bone scan was also undertaken in 15 patients within one week. All scintigraphically detected lesions were confirmed by histopathological analysis and (or) by other imaging modalities. Tumor to normal tissues ratios (T/N) were calculated. Results For 99 Tc m-sandostatin imaging,the sensitivity,specificity and accuracy in differentiating malignant from benign lesions were 93.3%,5/5 cases,94.3%,respectively. Two patients with squamous cell tumor were negative on 99 Tc m-sandostatin imaging. Four SCLC patients with positive scintigraphy with pleural metastases were documented by biopsy. In another 12 patients,bone metastases were documented on their bone imaging,only 5 patients were also positive on 99 Tc m-sandostatin imaging. In 5 patients with SPN, 99 Tc m-sandostatin imaging was negative,but high focal uptake was visualized with FDG coincidence imaging in 1 patient, the others show low FDG uptake or almost no uptake in the region of the radiographic abnormality,in their histopathologic findings proved benign lesions. For 99 Tc m-sandostatin imaging,T/N ratios were 3.43±0.66,2.24±0.31 in SCLC,NSCLC groups respectively,and had significant difference ( t =4.072,P <0.001). Conclusions 99 Tc m-sandostatin imaging is a promising noninvasive imaging method both for SCLC and NSCLC. It is readily available,safe and cost effective. Also,it may be a valuable novel peptide tracer for tumor imaging.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2004年第2期104-106,共3页
Chinese Journal of Nuclear Medicine
