摘要
骺板损伤可导致骨骺与干骺端之间形成骨桥,骺板提前闭合,造成肢体短缩和(或)成角畸形,影响儿童生长发育。早期诊断较困难,X线、CT、MRI等影像学检查及“骨桥地图法”可协助诊断。传统治疗有骨桥切除后以脂肪、骨水泥等填塞,但效果不一。近年来,随着显微外科及组织工程等新技术的开展,用培养的骺软骨细胞、间充质干细胞等移植代替无活力的填充物植入,它能不断增殖并抑制骨桥形成,将为骺板损伤治疗提供更好的解决方案。本文结合国内外最新研究成果对骺板损伤的现状进行回顾,并对其前景作一展望。
Epiphyseal plate injury may cause severe growth arrest becau se it results in the bony bridge between the epiphysis and metaphysis, earlier c losure of epiphyseal plate and limb reduction and (or) angulated deformity. It i s difficult to diagnose the injury early, though radiography, CT, MRI can help i ts diagnosis. Traditional treatments for bony bridge include packing an interpos itional material such as fat and bone cement after removal of the bone bar. Micr osurgical and tissue engineering techniques have brought out many new methods fo r the diagnosis and treatment of this growth injury. Growth plate chondrocytes a nd mesenchymal stem cells culture may provide the appropriate cartilage necessar y to restore growth potential when implanted in a growth plate defect, and preve nt transphyseal bone bridge formation. This article discusses the current develo pment and prospects for the diagnosis and treatment of growth plate injury.
出处
《中华创伤骨科杂志》
CAS
CSCD
2003年第4期365-366,373,共3页
Chinese Journal of Orthopaedic Trauma
基金
湖北省教委基金资助课题(2000B03002)
