摘要
目的 :评价老年乳腺癌患者术后早期应用泰索帝每周方案辅助化疗的耐受性 .方法 :老年乳腺癌患者 70例 ,均行乳腺癌简化根治术 ,随机分为A ,B两组 ,分别于术后第 3日和术后第 1 4日开始应用泰索帝每周方案辅助化疗 ,观察患者切口愈合状况、化疗后的近期毒性反应情况 .结果 :两组患者切口愈合状况无明显差异 .术后早期化疗的主要毒性反应为恶心、呕吐 ,经对症治疗后均可缓解 ,A组发生率为 4 1 .9% ,B组发生率为 4 4 .4 % ;化疗中后期毒性反应主要为白细胞减少 ,多为I～II度 ,两组发生率分别为 1 6 .3%和 1 4 .8% ,无严重不良反应发生 ,两组比较无显著差异 (P >0 .0 1 ) .结论 :高龄乳腺癌患者术后早期应用泰索帝每周方案辅助化疗是安全的 。
AIM: To discuss the tolerance of weekly scheduled administration of docetaxel in elder patients shortly following mammectomy. METHODS: Seventy elder patients with breast cancer were divided into 2 groups and Doxetaxel was administrated on the 3rd and 14th day respectively after operation. Healing of incision and response to chemotherapy were observed. RESULTS: There was no significant difference in incision healing between the two groups and the major side effects at the early stage of chemotherapy were nausea and vomiting, which were relieved after treatment. The occurrence rate of group A and B was 41.9% and 44.4%, respectively. I-II grade leucopenia was found at the late stage of chemotherapy and the occurrence rate of group A and B was 16.3% and 14.8%, respectively. There was no significant difference between the two groups and no other severe side effects were observed in both groups. CONCLUSION: The weekly scheduled administration of docetaxel in elder patients shortly following mammectomy is safe and well tolerated.
出处
《第四军医大学学报》
北大核心
2004年第9期854-855,共2页
Journal of the Fourth Military Medical University
关键词
乳腺癌
泰索帝
化疗
毒性反应
breast neoplasms
docetaxel
chemotherapy
toxic reaction
