摘要
周围神经损伤后雪旺细胞增殖,轴突再生。雪旺细胞在周围神经损伤再生时至关重要。本文综述雪旺细胞在周围神经损伤后生存和凋亡的调节:①大量分泌NGF,②表达P75,③分泌IGF-2、PDGF-BB、NT-3及CNTF,④假设在增殖的雪旺细胞群中存在着维持其生存和凋亡的动态平衡。进一步提出是否需重新评价外源性NGF在周围神经中促进轴突再生的价值的问题。
Schwann cells proliferate and the axis cylinder regenerates after the injury of the peripheral nerves. Schwann cells are a vital factor in the process of regeneration of injured nerves. The article summarizes the survival and apoptosis adaptation of Schwann cells after the injury of the peripheral nerves. It discusses massive NGF secreting, P75 expressing, and IGF 2, PDGF BB, NT 3 and CNTF secreting. It also supposes that there might be a homeostasis between survival and apoptosis in the proliferated Schwann cells and brings forward the question regarding reassessment of administration of NGF to enhance regeneration of the injured peripheral nerves.
出处
《中华创伤骨科杂志》
CAS
CSCD
2004年第3期330-333,共4页
Chinese Journal of Orthopaedic Trauma
