摘要
本文对101例健康人包括中青年组(20～40岁)31例,老年前期(45～59岁)31例,老年组(≥60岁)39例分别作RP_1,RP_2、RP(2-1)、RP(μ-s)、PEP、SOD、LPO、T_3、T_4、TSH、Zn、CuA、Ig、IgG和IgM等15项衰老生物标记测定。得出SOD中青年组1323±149(sigma U/gHb),随增龄而减少至老年组1184±103(sigma U/gHb)(P<0.01),不受性别影响,可作衰老敏感标记;RP(2-1)老年组32.95±13.53(ms)较中青年组44.55±15(ms)传导时间短(P<0.01),提示随增龄血管弹性减低,阻力负荷增加,可作为心血管衰老生物标记之一;TSH虽随增龄有所提高,但性别间有差异,要排除影响因素也可作标记之一;Zn、Cu、IgA仅在男性组随年龄有改变,故尚不能作为敏感衰老生物标记。
101 healthy persons were divided into 3groups. The 1st gronp was woung adnlts(20-44 years old),the 2nd group was middle aged (45-59 years old),and the 3rd groupwas the aged (over 60 years old). 15 paramsters (RP_1, RP_2, BP(2-1), BP(u-s), PEP,SOD, LPO, T_3, T_4, TSH, Zn, Cn, IgA, IgG, IgM) were determined. The levels ofSOD and BP(2-1) in old persons were found significantly decreased paralleled withtheir age bnt with no sex differences. So that, they could be served as Biomarkersof senile persons. There were also obvions difference in TSH levels among thesethree groups, with sex difference. No change was found in other parameters. ThePathogenesis of senility was also discussed.
出处
《老年学杂志》
CSCD
1989年第3期153-157,191,共5页
关键词
衰老
生物标记
SOD
Biomarkers of senile person
SOD (Superoxide dismntise)
RP(pulse wave transit time)
