摘要
目的 了解职业性低剂量外照射对射线工作者的细胞遗传学影响。方法 采用微量全血培养法,按1973年世界卫生组织的建议分析畸变细胞;职业外照射剂量,采用TLD剂量计测得。结果 ①照射组的畸变细胞率为0.688%,比对照组的0.225%差异有非常显著性(P<0.01),其中无着丝粒畸变、稳定性畸变、染色体体型畸变、单体型畸变等指标照射组比对照组均有显著意义的增加(P<0.01);②各类型的染色体体型畸变率随着年剂量的增加而升高,最高的年剂量当量组(3～5mSv/a)畸变细胞率为1.670%,染色体体型畸变率为1.670%,单体型畸变率2.000%;③在放射工龄比较中,工龄10年以上组各类型畸变率最高,但各工龄组比较差异无显著性(P>0.05)。结论 长期受职业性小剂量外照射可引起染色体畸变率增高。因此,必须做好放射卫生防护工作。
Objective To study the cellular genetic effect of low-dose Occupational radiationexposure in medical X-ray workers. Methods Full blood Samples were cultured and aberrative cells wereanalyzed with microscope. Occupational radiation dose was detected by TLD dose meter. Result (1) Therates of aberration cells were 0.688% in the radiative group and 0.225% in the controlled, and there wasa very significant difference (P<0.01) between them. In the radiation group, some indexes such asakinetic aberration, stabilizing aberration, chromosome somatotype aberration, monosome aberration alsovery significantly increased (P<0.01). (2) The rate of chromosome somatotype aberration increased withthe increase of the annual radiation doses, the rate of cell aberration being 1.670%, the rate ofchromosome somatotype aberration 1.670%, and the rate of monosome aberration 2.000% in the highest dosegroup. (3) Compared with the length of service, aberration rate was highest in the workers served longerthan 10 years, but no significant differences existed (P>0.05) with the those served shorter. Conclu-sion Long-term low-dose radiation exposure could increase the chromosome aberration rate. Radiationprotection should tighten in the medical X-ray workers.
出处
《国际医药卫生导报》
2004年第10期12-13,共2页
International Medicine and Health Guidance News
关键词
染色体畸变
医用诊断X射线工作者
年剂量
Chromosome aberration Medical X-ray worker Annual radiation doses
