摘要
目的 探讨胃动素 (MTL)与胎儿宫内缺氧的关系及在胎儿羊水粪染发病中的作用。方法 应用放射免疫法测定 34例足月分娩有不同程度羊水粪染新生儿脐血血浆中胃动素浓度 ,并以 34例正常新生儿作为对照。结果 (1)Ⅰ度、Ⅱ度、及Ⅲ度羊水粪染组新生儿脐血MTL值分别为 30 0 .0 2± 10 8.76pg/ml、35 9.35± 14 4 .4 8pg/ml及 382 .18± 199.0 2 pg/ml ,其中Ⅱ度、Ⅲ度较正常新生儿 (2 4 1.15± 5 9.2 2 pg/ml)及Ⅰ度污染组明显增高 ,两者之间差异均有显著性 (P <0 .0 1)。Ⅰ度污染组与正常对照组比较 ,差异无显著性 (P >0 .0 5 )。 (2 )新生儿窒息组脐血MTL(346 .80± 14 8.87pg/ml)略高于窘迫组 (32 4 .0 1± 15 5 .17pg/ml) ,差异无显著意义 (P >0 .0 5 ) ,与正常对照组 (2 33.5 0± 83.10 pg/ml)相比差异有非常显著意义 (P <0 .0 1)。 (3)阴道助产组脐血MTL(36 1.6 4± 172 .11pg/ml)与剖宫产组 (2 5 9.2 2± 92 .37pg/ml)相比 ,显著差异 (P <0 .0 1) ,与自然分娩组 (2 76 .6 3± 12 6 .94 pg/ml)相比也有差异 (P <0 .0 5 ) ;自然分娩组略高于剖宫产组 ,但无统计学差异 (P >0 .0 5 )。结论 血中胃动素浓度在胎儿宫内缺氧时增高 ,不仅与羊水粪染的发生有关 ,而且与其严重程度有关 。
Objective: To study the relationship between amnioinfusion and motilin plasma concentrations in umbilical cord of term fetal,and to explore effect of motilin on amnioinfusion. Methods: Motilin plasma concentrations was measured by radioimmuno-assay in cord venous blood from 34 infants with amnioinfusion, and compared with that of 34 healthy infants. Results: (1) Plasma motilin concentration in infants with degree Ⅰ?Ⅱ and Ⅲ of amnioinfusion were(300.02±108.76)pg/ml?(359.35±144.48 ) pg/ml and (382.18±199.02)pg/ml, respectively .The levels of motilin with degree Ⅱ?Ⅲ amnioinfusion were significantly higher than that of healthy infants[(241.15±59.22)pg/ml] and that of degree Ⅰ,( P <0.01). There was no significantly difference in cord venous blood motilin levels between infants with degree Ⅰ amnioinfusion and healthy infants( P >0.05).(2) Motilin plasma concentrations of umbilical cord in newborn with birth asphyxia group and fetal distress group (346.80±148.87 pg/ml and 324.01±155.17 pg/ml, respectively) was and significantly higher than the healthy infants groups (233.50±83.10 pg/ml)( P <0.01). (3) Motilin plasma concentrations of umbilical cord in assisted delivery group(361.64±172.11 pg/ml)was significantly higher than that in cesarean section group (259.22± 92.37 pg/ml)( P <0.01), and also higher than that in normal delivery group(276.63±126.94pg/ml)( P <0.05). Motilin plasma concentrations of umbilical cord in cesarean section group and normal delivery group have no obvious difference( P >0.05). Conclusion: Motilin plasma concentrations of umbilical cord was high in infants with hypoxia in uterine.High motilin plasma concentrations was not only related to amnioinfusion, but also to its severity. Our finding suggests that motilin may play an important role in amnioinfusion.
出处
《中国优生与遗传杂志》
2004年第2期79-80,106,共3页
Chinese Journal of Birth Health & Heredity
