摘要
目的:探讨高脂血症表型与脂肪肝形成之间的关系及临床特点. 方法:收集脂肪肝病例413例,伴高脂血症的脂肪肝患者258例,为高脂血症脂肪肝组;随机抽取上述时间段非脂肪肝患者200例,作为对照组,其中高脂血症的61例, 为高脂血症非脂肪肝组.Logistic回归方程分析高脂血症表型与脂肪肝形成的关系.比较各型高脂血症脂肪肝的临床并发症及肝功能的差异. 结果:413例脂肪肝中,高甘油三酯(TG)血症和混合性高脂血症的比例明显高于对照组.混合性高脂血症和高FG血症与高胆固醇(CHO)血症相比,其发生脂肪肝的优势比(OR)分别为5.966和2.960.高脂血症脂肪肝组合并Ⅱ型糖尿病、肥胖、高血压、高尿酸血症、以及ALT和GGT升高的比例显著高于高脂血症非脂肪肝组.脂肪肝患者各型高脂血症之间合并Ⅱ型糖尿病、肥胖、高血压、冠心病、高尿酸血症和胆石症的比例无显著差异. 结论:脂肪肝的形成与患者合并混合性高脂血症和高TG血症有关.高脂血症脂肪肝组相关并发症发生的比例较高脂血症非脂肪肝组高,且肝功能损害较明显,但与高脂血症的表型无关.
AIM: To investigate the association between the formation of fatty liver and the phenotypes of hyperlipidemia. METHODS: A total of 258 patients with hyperlipidemia were found in 413 patients with fatty liver, and 61 cases of hyperlipidemia in non-fatty liver patients were selected randomly as controls. The complications and liver function abnormalities were compared between two groups. RESULTS: The proportion of hypertriglyceridemia and mixed hyperlipidemia was higher in the patients with fatty liver than non-fatty liver. Odds ratios (OR) of finding fatty liver in the patients with mixed hyperlipidemia and hypertriglyceridemia were 5.966 and 2.960 respectively, relative to hypercholesterolemia. The percentage of complications of type Ⅱ diabetes mellitus, obesity, hypertension, hyperuris-emia and the evelation of serum alanine aminotransferase (ALT), γ-glutamyltransferase (GGT) were higher in patients with fatty liver than non-fatty liver. But, there were no differences in coincidence of diabetes mellitus, obesity, hyperten-sion, hyperurisemia, coronary heart disease, choelithiasis among various phenotypes of hyperlipidemia. CONCLUSION: The pathogenesis of fatty liver can be related to mixed hyperlipidemia and hypertriglyceridemia. The complications of patients with fatty liver may be more common than those with non-fatty liver, but have no dif- ferences of complications among various phenotypes of hyperlipidemia.
出处
《世界华人消化杂志》
CAS
2004年第4期914-916,共3页
World Chinese Journal of Digestology
