摘要
目的 探讨脊髓损伤后三七总皂甙 (totalsaponinsofpanaxnotoginseseng ,PNS)对脊髓血流量及神经功能的影响。方法 Wistar大鼠 2 0只 ,随机分为生理盐水对照组 (NS组 )和PNS治疗组 (PNS组 )。Allen’s打击法 5 0gcm ( 5g× 10cm)致伤大鼠L1 L2 段脊髓 ,立即腹腔注射PNS(生理盐水配制 ,10ml kg ,2 0mmol L) ,于伤前、伤后即刻、1、3、6、2 4h分别记录T13段脊髓血流量、脊髓感觉诱发电位。结果 与盐水对照组比较 ,应用PNS后 ,大鼠SCBF、SEP明显优于生理盐水对照组 (P <0 0 5 )。结论 大剂量PNS能有效改善损伤早期脊髓微循环 。
Objective To investigate the effects of total saponins of panax notoginseng (PNS) on spinal cord blood flow (SCBF) and the function after spinal cord injury. Methods A total of 20 Wistar rats were randomly divided into normal saline group (NS) and PNS treated group (PNS). PNS (10 ml/kg, 20 mmol/L) was injected into the abdominal cavity of rats immediately after traumatic injury of the L 1 L 2 segmental spinal cord was made by using Allen's method 50 gcm (5 g×10 cm). The SCBF and sensory evoked potential (SEP) of T13 segment were recorded before injury and at 0, 1, 3, 6, and 24 h after injury. Results SCBF and SEP of rats administered with PNS were much higher than those of the rats in group NS ( P <0 05). Conclusion High dose PNS can improve the spinal cord blood flow and protect the functions of injured spinal cord at the early stage.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2004年第3期212-213,共2页
Journal of Third Military Medical University
关键词
脊髓损伤
三七总皂甙
脊髓血流量
感觉诱发电位
spinal cord injury
total saponins of panax notoginseng
spinal cord blood flow, sensory evoked potential
