摘要
采用常规微电极技术,用离体肠鼠心乳头肌观察了Protopine对正常心肌细胞动作电位和收缩力的影响。结果表明:Protopine产生浓度依赖性负性肌力作用。Vmax也呈现浓度依赖性降低,APD20、APD50、APD90不呈现浓度依赖性变化,但ERP随Protopine的浓度增加不断延长。提示Protopine的抗心律失常作用可能与ERP的延长有关。
We observed the influence of protopine on action potential of isolated papillary muscles from the guinea pig using microelectrode technique. Protopine produced negative concentration-dependent inotropic effect.V_(max) was reduced by protopine also in a concentration-dependent manner. The changes of APD_(20), APD_(50) and APD_(90) were not concentration-dependent, but ERP was prolonged gradually following the increase of protopine concentration.
These results suggest that the antiarrhythmic effect of protopine can be explained by the prolongation of ERP.
出处
《昆明医学院学报》
1989年第1期44-46,共3页
Journal of Kunming Medical College
关键词
普罗托品
乳头肌
动作电位
收缩力
Protopine
Papillary muscle
Action potential
Contractility
