摘要
目的 :探讨冠心病患者经皮冠状动脉介入治疗 (PCI)前后血丙二醛 (MDA)、超氧化物歧化酶 (SOD)及左心室功能的变化及其与冠状动脉侧支循环的关系。方法 :选择接受PCI的 75例冠心病患者 ,根据冠状动脉造影结果分为无侧支循环组 (4 4例 )和侧支循环组 (31例 ) ,在术前及术后分别测定静脉血MDA、SOD水平 ,用超声心动图测定左心室射血分数(LVEF)及Tei指数。结果 :两组术后 2h静脉血MDA升高、SOD降低 (均P <0 .0 1) ,术后 2 4h无侧支循环组MDA回降、SOD上升 ,与术前比较仍有显著性差异 (P <0 .0 1) ;两组间PCI后MDA、SOD及Tei指数有显著性差异 (P <0 .0 5 ,P <0 0 1)。结论 :冠状动脉侧支循环能减轻冠心病患者PCI治疗后的心肌再灌注损伤。
Objective:To investigate the relationship between coronary artery collateral circulation and myocardial reperfusion injury after percutaneous coronary intervention (PCI).Methods:75 patients with coronary artery disease were divided into patients without collateral group (n=44) and patients with collateral group (n=31) according to the results of coronary angiography. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured before and 2 hours and 24 hours after PCI. And cardiac: function were detected before and 24 hours after PCI with two dimension and Doppler echocardiography.Results:MDA was increased and SOD decreased 2 hours after PCI in all patients (both P<0.01) and MDA was increased and SOD decreased 24 hours after PCI in patients without collateral group (P<0.01).There were significant differences between two groups in serum MDA,SOD,and Tei index after PCI(P<0.05,P<0.01).Conclusion:Coronary artery collateral circulation might abate myocardial reperfusion injury in patients with coronary artery disease after PCI.
出处
《医学影像学杂志》
2004年第2期105-108,共4页
Journal of Medical Imaging
关键词
冠状动脉
放射学
介入性
侧支循环
TEI指数
再灌注损伤
Coronary artery
Radiology,interventional
Collateral circulation
Tei Index
Reperfusion injury
