摘要
本研究结果显示,严重烧伤病人全身性感染发生率为30.9%,未得到控制者均出现感染性休克和多脏器衰竭(MOF),MOF发生率和死亡率均达76.5%。感染组血浆血栓素B_2(TXB_2)和TXB_2/6—酮—前列腺素F_(1α)(6—酮—PGF_(1α))比值均增高,后者于伤后初期和3～7天两度增高,与全身性感染发生时间一致。循环血小板微聚物比率明显降低,心肌酶谱示CPK、LDH、GOT值均明显增高,死亡病人主要脏器组织可见血栓形成,表明TXA_2/PGI_2失衡促使微聚物和血栓形成是严重烧伤感染导致感染性休克和MOF的机理之一。
The results of this study demonstrated that the incidence of systemic infection in severe burn patients was 30.9%. All the uncontrolled cases developed infectious shock and multiple organ failure (MOF). The morbidity and mortality of MOF in those patients was 76.5%, respectively. In the infected group, levels of plasma TXB_2 and TXB_2/6-keto-PGFla ratio increased markedly. The later was increased twice during the early stage and 3 to 7 days postburn, which was in accordance with the clinical course of occurrence of systemic infection. Circulatory platelet aggregate ratio significantly decreased, while myocardiac enzyme spectrum greatly increased. Thrombus was found in the main visceral tissues from patients died of systemic infection. These findings substantiated that TXA_2/PGI_2 imbalance prompting microaggregate and thrombus formation was one of the pathogenesis of infectious shock and MOF caused by systemic infection in severe burn Patients.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1992年第6期357-359,共3页
Chinese Journal of Trauma
关键词
烧伤
微聚物
血栓素
前列环素
Burn Systemic infection Microaggregate Thromboxane Prostacyclin
