摘要
应用电子计算机及多因素逐步回归分析方法,对80例不同预后(术后生存时间<5年或≥5年)的结直肠癌患者的3个临床病理指标和5个计量病理指标进行分析,结果显示,临床病理指标组织学分级和临床分期,计量病理指标DNA含量和核浆比,4个指标与预后关系密切。用它们建立回归方程,区分术后生存时间<5年组和≥5年组,两组差别显著(P<O.001)。回归方程的回代法和刀切法检验的效率分别为82.5％和80.0％,敏感性分别为 60.2％和87.8％。以上结果说明,临床病理指标与计量病理指标结合通过电子计算机进行多因素分析,可以对结直肠癌患者的预后作出比较切合实际的估计,具有一定的临床应用价值。
Three clinicopathologic parameters and five quantitative pathologic parameters in 80 colorectal carcinoma patients with different outcome (<5 years or ≥5 years postoperatively) were studied by a stepwise regression analysis using computer. The result showed that DNA ploidy, nucleocytoplasmic ratio, histologic grade and clinical stage were significant factors influencing prognosis. Based on these factors, a 4-variable regression function was established, which could correctly identify 80% of the predicted cases and 87.80% of the cases who may have a less than 5 years postoperative survival period (Jackknife procedure). This result indicates that clin- icopathologic parameters combined with quantitative pathologic parameters are quite valuble in predicting the progncsis of colorectal carcinoma patients.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1992年第1期36-38,共3页
Chinese Journal of Clinical Oncology
关键词
计量病理学
结肠肿瘤
直肠肿瘤
癌
Colo-rectal cancer
Multivariate stepwise regression analysis
Prognostic factors
Quantified pathology
