摘要
本实验比较观察益气活血及疏肝理气两类治则方药对家兔实验性高脂血症及动脉粥样硬化的影响,并从胆汁脂质成份、血浆LPO浓度、环核苷酸及TXA_2-PGI_2水平、血液流变学等指标探讨其机理。结果发现:(1)两类治则方药均有降血胆固醇、改善动脉粥样斑块的作用,且前方优于后方;(2)两类治则方药均能改变胆汁中脂质含量,减少胆石生成,但后方优于前方;(3)改善动脉粥样硬化的机理与降低血脂、降低LPO、提高cAMP/cGMP及改善TXB_2/6-KPGF_(1α)比值有关。实验提示不同方剂可因作用于相同发病环节而起到同病异治的作用。
This paper reports the treatment with Yiqi Huoxue and Shugan Liqi agents in atherosclerosis of rabbit. The results suggested: 1. Both decoctions could reduce the cholesterol of hypercholester-olemia and improve the atherosclerosis, but the former was better than the latter. 2. Both decoctions could alter the components of bile lipids, but on the contrary, the latter was better than the former in reducing the formation of gallstones. 3. Both decoctions could decrease the plasma concentration of LPO and ratio of TXB2/6-K-PGF_1α, while increase the ratio of cAMP/cGMP in plasma. So, the different prescriptions of TCM affecting the same link of pathogenesis might play the role of 'Different Treatments in Same Disease'.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1992年第7期417-420,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金(3870538)
关键词
动脉粥样硬化
益气活血
胆结石
atherosclerosis
cholelithiasis
different diseases with same treatment
Yiqi Huoxue
Shugan Liqi
